in Nucleic Acid Therapeutics for Human Health


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Subretinal fibrosis (SRF)

  • Subretinal fibrosis (SRF) is defined as the development of disciform scar and fibrosis underneath the retina which can cause vision loss through macular edema and detachment.
  • The irreversible fibrosis development is closely associated with most of the major ocular diseases such as wet AMD, diabetic retinopathy (DR), central retinal vein occlusion (CRVO), and so on, but there is no FDA-approved treatment for this condition.

Development status

  • Development under consultation with a science advisory board member, Prof. Demetrios Vavvas at Harvard Medical School
  • The potential of a first-in-class therapeutic to treat SRF and CNV(Choroidal Neovascularization) in wet AMD patients
  • Promising efficacies in animal models for SRF and CNV are confirmed (ongoing)
  • Expects to submit an IND for a Phase 1 clinical trial in USA