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Platform Technology

RNAi platform development

Lead compound discovery

Pulmonology / Neurology

Pharmacological research on OliX RNAi compounds for respiratory and neurological diseases

Ophthalmology

Pharmacological research on OliX RNAi compounds for ocular diseases

Animal Research

Testing efficacy of oligonucleotide therapeutics using animal models

Analytics

Develop analytical methods for therapeutic candidates to determine purity and stability in support of nonclinical and clinical studies

PK/TK

Develop bioanalytical methods to quantitate therapeutic candidates in biological matrices for pharmacokinetic and toxicokinetic (PK/TK) studies

CMC

Manage manufacturing, analytics and quality of therapeutic candidates

Toxicology

Conduct safety evaluation and toxicokinetic assessment of therapeutic candidates through nonclinical studies

Clinical

Establish clinical development plans for therapeutic candidates and conduct clinical studies

Management

Business Management

Purchasing

General Affairs

Facility Management

Contingency Planning

Planning

Budget/Performance Management

Mid to Long-term Business Goals/Strategy Planning

Accounting & Finance

Make official announcements about business contents, financial condition, business performance etc.

Stabilize Internal Accounting Control System

IT

IT Infrastructure Management

IT Helpdesk

Human Resources

HR Policy/System Establishment, Organization/Job Design

Recruitment/HR Management

Performance Management, Employee Welfare

HR Development

Legal Affairs

Prevent, respond, handle legal disputes

Provide risk management and compliance support

Develop IP strategies for core technologies

Quality Assurance(QA)

Verify pharmaceutical R&D processes and results

Ensure product to meet the established quality standards

Business Development

Develop/Maintain Client Relationships

Execute Licensing Agreements

New Business/Strategy Planning

Communications

Provide investment information in a timely manner to increase company value

Promote management activities and establish internal/external communication strategies

Create positive corporate culture through various in-house activities and employee education

Home
R&D

R&D

OliX Pipeline

OliX Pipeline

Pipeline
OLX101A
OLX201A
OLX301A
OLX301D

Age-Related Macular Degeneration (AMD)

• Occurs when the small central portion of the retina, known as the macula, deteriorates

• The leading cause of severe vision loss in people over age 60 in developed countries

• Two types: wet AMD (10%) and dry AMD (90%)

Market Potential

• Leading cause of vision loss globally; no. 1 disease for vision loss in developed countries

• Steady increase of AMD patients globally: 200 million patients in 2020, 3 million patients expected in 2040

• AMD patients in the US estimated to be 1.75 million in 2014 (source : All about vision, Understanding AMD 2014)

• The global AMD market size has been projected to reach $18.7B by 2028 (Source: GlobalData 2020)

Development Status

• Animal efficacy test currently underway at University of Virginia School of Medicine (Collaboration with Dr. J. Ambati, Department of Ophthalmology)

• Outstanding efficacy identified from animal models with dry macular degeneration

• License and Collaboration Agreement with Théa Open Innovation (Territory: EU, MEA, Africa, 2019.03.15)

• Expanded License and Collaboration agreement with Théa Open Innovation (Territory: Worldwide excl. Asia-Pacific)

• Preclinical toxicology studies with Charles River Laboratories